Scientific Program

Scientific Program

Download pdf of program

Friday, October 19

Arrival and check into the Graduate Hotel, Ann Arbor

Saturday, October 20

All sessions will be held at the University of Michigan Medical School in the A. Alfred Taubman Biomedical Science Research Building (BSRB) Kahn Auditorium (109 Zina Pitcher Place) unless otherwise noted.  
7:00 AM - 5:30 PM Registration
8:25 AM - 8:30 AM Welcome & Introductions
Asma Nusrat, MD and Charles Parkos, MD, PhD (University of Michigan)

Focus on Women’s Cancers
Co-Chairs:
Kathleen Cho, MD (University of Michigan)
Peter Lucas, MD, PhD (University of Pittsburgh)

8:30 AM - 9:00 AM Peter Lucas, MD, PhD (University of Pittsburgh)
Aberrant GPCR Signaling Mechanisms Driving Unique Subsets of Breast Cancer
9:00 AM - 9:30 AM Celina Kleer, MD (University of Michigan)
Investigating Mechanisms of the Matrix Protein CCN6 as a New Determinant of Metaplastic Breast Cancer

9:30 AM - 10:01 AM

9:30 AM - 9:33 AM


9:34 AM - 9:37 AM


9:38 AM - 9:41 AM


9:42 AM - 9:45 AM

 

9:46 AM - 9:49 AM


9:50 AM - 9:53 AM


9:54 AM - 9:57 AM


9:58 AM - 10:01 AM

Poster Blitzes (3-minute poster presentations):


Aaron Lim - "Renal Cell Carcinoma Package Immunosuppressive Cargo into Exosomes"
(Abstract # CAN1)

Jean-Francois Rual - "Characterization of the Role of L3MBTL3 in Breast Cancer"
(Abstract # BC3
)

Andrei Ivanov - "Adducins are Multifunctional Regulators of Lung Cancer Cell Migration"
(Abstract # CAN3)

Yuhua Xue - "
Glypican 3 (GPC3) Cross Talks with HGF/c-Met Axis in Hepatocytes and Hepatocellular Carcinoma (HCC) by Modulating p-Ezrin Dependent Hippo Pathway"
(Abstract # PLK6)

Qiushu Chen - "Chromatin Laser Imaging Reveals Abnormal Nuclear Changes Induced by Dietary Fat for Early Tumor Detection in Colon"
(Abstract # CAN9)

Gozde Uzunalli - "Pathology of Blood-Tumor Barrier in Brain Metastasis of Lung Cancer"
(Abstract # CAN11)

Kelvin Jones - "Identification of Novel Peptides Against Breast Cancer Cells Undergoing EMT Utilizing Phage Display"
(Abstract # BC7)

Leon Friesen - "Regulation of Inflammation and Cancer in the Colon by Dietary Fiber and their Microbial Metabolites: Roles of Barrier Function and Tissue Bacteria"
(Abstract # CAN17)

10:02 AM - 10:15 AM Break
10:15 AM - 10:30 AM Abstract-Driven Short Talk
Sreedhar Reddy Suthe, B.Pharm (Texas Tech University Health Sciences Center)
RON-Targeted Antibody-Drug Conjugate Therapy Ablates Cancer Stem Cells and Induces Long-term Tumor Regressions in Preclinical Models of Triple Negative Breast Cancer” (Abstract # BC6)
 
10:30 AM - 11:00 AM Kathleen Cho, MD (University of Michigan)
Modeling “Ovarian” Cancers in the Mouse: Progress, Pitfalls and Potential New Platforms for Translational Applications
11:00 AM - 11:15 AM Abstract-Driven Short Talk
Melanie Rivera, BS (University of New Mexico)
Rac1 as a Driver in Ovarian Cancer Metastasis” (Abstract # CAN5)
11:15 AM - 11:45 AM

Analisa DiFeo, PhD (University of Michigan)
"A miRNA-Mediated Approach to Dissect the Complexity of Ovarian Tumor-Initiating Cells and Identify miRNA-Targeting Drugs"

Lunch Session -
ABC Seminar Room
Co-Sponsored by the ASIP Education Committee and the ASIP Committee for Career Development and Diversity

12:00 PM - 1:00 PM

 

 

1:00 PM - 1:30 PM

Kelsey Dillehay McKillip, PhD (University of Cincinnati)
Maximizing Biospecimen Resources

Moderator: Diane Bielenberg, PhD

Q & A with Panelists:
Kelsey Dillehay McKillip, PhD, Daniel Remick, MD,  
Mark Sobel, MD, PhD

 

From Investigation to Translation: The Growing Role of Molecular Pathology in Clinical Diagnostics
Co-Chairs:
David Williams, MD, PhD (University of North Carolina)
Nathan Montgomery, MD, PhD (University of North Carolina)

1:30 PM - 2:00 PM Nathan Montgomery, MD, PhD (University of North Carolina)
New Insights into HIV-Associated Lymphomagenesis
2:00 PM - 2:30 PM Arul Chinnaiyan, MD, PhD (University of Michigan)
The Application of Integrative Sequencing for Precision Oncology

2:30 PM - 3:01 PM

2:30 PM - 2:33 PM



2:34 PM - 2:37 PM

 

2:38 PM - 2:41 PM

 

2:42 PM - 2:45 PM

 

2:46 PM - 2:49 PM

 

2:50 PM - 2:53 PM
 


2:54 PM - 2:57 PM



2:58 PM - 3:01 PM

Poster Blitzes: (3-minute poster presentations)


Maria Gonzalez - "DDR2-depleted Mesenchymal Stem Cells Attenuate the Tumor-promoting Effect of Breast Cancer Cell Engulfment"
(Abstract # BC1)

 

Triet Bui - "Neutrophils Promote Non-Homologous End-Joining (NHEJ)-mediated Survival of Tumor Cells in Inflammation-driven Tumorigenesis" 
(Abstract # CAN2)

 

Diane Bielenberg - "Investigating The Neuropilin-2/Semaphorin-3F Pathway In Melanoma”
(Abstract # CAN13)

Benoit Niclou - "Semaphorin3F as a Novel Targeted Therapy Against PDAC"
(Abstract # CAN10)

 

Jacqueline Jones - "FOXI3: It’s a "Bone" Attraction to Promoting Cancer Progression"
(Abstract # CAN12)

 

Sabra Djomehri - "A Scaffold-free 3D Organoid Model to Study Neoplastic Progression in Breast Cancer"
(Abstract # BC8)

 

Wenyi Liu - "Detecting Bladder Cancer Through Urinary Survivin by Automated Microfluidic ELISA"
(Abstract # CAN15)

 

Moloy Goswami - "Identification and Characterization of TPRKB Dependency in p53-deficient Cancers"
(Abstract # CAN19)

3:02 PM - 3:15 PM Break
3:15 PM - 3:30 PM Abstract-Driven Short Talk
Andi Cani, MS (University of Michigan)

"Development of a Whole Urine, Next Generation Sequencing-Based Assay for Early Detection of Aggressive Prostate Cancer"
(Abstract # CAN16)

 

3:30 PM - 4:10 PM Gregory Tsongalis, PhD (Dartmouth-Hitchcock Medical Center)
The Trek from Lebanon to Honduras: The Impact of Near Patient Testing in an LMIC
4:10 PM - 5:45 PM Poster Session (includes refreshments)
 

          Poster Topic Categories:

Breast Cancer                                                       BC1 through BC10
Cancer                                                                    CAN1 through CAN23
Pathobiology of Liver and Kidney                      PLK1 through PLK10
Stem Cells and Regenerative Medicine            SCRM1 through SCRM5
Neuropathology                                                    NEURO1 through NEURO5

5:45 PM Free night - Visit Michigan

Sunday, October 21

Inflammation: The Nexus of Innate and Adaptive Immunity
Co-Chairs:
Tanya Mayadas, PhD (Brigham and Women's Hospital)
Pilar Alcaide, PhD (Tufts University School of Medicine)

7:00 AM - 5:30 PM Registration
8:25 AM - 8:30 AM Welcome & Introductions
Asma Nusrat, MD and Charles Parkos, MD, PhD (University of Michigan)
8:30 AM - 9:00 AM Mark Miller, PhD (Washington University School of Medicine)
Acute Host Responses to Infection and Inflammation at Mucosal Barriers
9:00 AM - 9:30 AM Tanya Mayadas, PhD (Brigham & Women's Hospital)
Neutrophil FcgRs in the Regulation of Immune Responses

9:30 AM - 10:01 AM

9:30 AM - 9:33 AM


9:34 AM - 9:37 AM


9:38 AM - 9:41 AM


9:42 AM - 9:45 AM


9:46 AM - 9:49 AM


9:50 AM - 9:53 AM


9:54 AM - 9:57 AM


9:58 AM - 10:01 AM

Poster Blitzes: (3-minute poster presentations)
 

Heather Grifka-Walk - "Discovery of a Protective and Transmissible Microbiome that Alters Intestinal and Systemic Inflammatory Responses"
(Abstract # GMD4)

Prarthana Dalal - "Calmodulin and CaMKII Play a Role in Leukocyte Transmigration"
(Abstract # INIM2)


Yang Mei - "Diaphanous-related Formin Protein mDia2 Regulates Hematopoietic Stem and Progenitor Cell Functions Through SRF-Integrins Pathway"
(Abstract # SCRM1)

Atsushi Hayashi - "Impaired IL-22 Production by RORγt+ILC3s in Crohn's Disease"
(Abstract # EMP3)

Vicky Garcia-Hernandez - "Stem Cell Factor Inhibition Enhances Recovery from Colitis"
(Abstract # EMP5)

Zachary Wilson - "Vinculin Accumulates Pulmonary Interstitial Neutrophils in a Murine Model of Acute P. aeruginosa Pneumonia"
(Abstract # INIM9)


Jennifer Bermick - "Neonates Are Uniquely Susceptible to Escherichia coli K1 Sepsis Due to Excess Iron"
(Abstract # ID2)


Alexander Dowdell - "HIF-dependent Regulation of Salmonella-induced Autophagy in Intestinal Epithelia"
(Abstract # EMP9)

10:02 AM - 10:15 AM Break
10:15 AM - 10:30 AM Abstract-Driven Short Talk

Paul Bernard, BS (Texas A&M College of Medicine)
"RocA is an Important Regulator with Serotype-specific Pathogenesis Functions in Serotype M28 Group A Streptococcus"
(Abstract # ID1)

10:30 AM - 11:00 AM Simon Hogan, PhD (University of Michigan)
Intestinal Epithelial Allergen Sampling and Food Allergy
11:00 AM - 11:15 AM Abstract-Driven Short Talk

Hirohito Abo, PhD (Georgia State University)
"Maternal Microbiota Exposure Regulates Colonic Erdr1 Expression in Offspring"
(Abstract # GMD2)

11:20 AM - 12:00 Noon Rous-Whipple Award Lecture
Gabriel Nunez, MD (University of Michigan)
Role of the Microbiota in Host Defense and Inflammatory Disease
Lunch Session - ABC Seminar Room
12:20 PM - 12:25 PM        Introductions - Satdarshan (Paul) S. Monga, MD
12:25 PM - 12:40 PM Bethany Moore, PhD (University of Michigan)

"Herpes Virus and IL-17 Drive Pneumonitis and Fibrosis Post-stem Cell Transplant"

12:40 PM - 12:55 PM Youhua Liu, PhD (University of Pittsburgh)
Molecular Dissection of the Fibrogenic Niche in Kidney Fibrosis
12:55 PM - 1:10 PM Satdarshan (Paul) S. Monga, MD (University of Pittsburgh)
Targeting Activated Myofibroblasts in Liver Fibrosis
1:10 PM - 1:25 PM Meet the Experts - Open Discussions

Cell Death, Tissue Injury and Repair
Co-Chairs:
Andrei Ivanov, PhD (Cleveland Clinic Foundation)
Jennifer Brazil, PhD (University of Michigan)

1:30 PM - 2:00 PM Andrew Neish, PhD (Emory University School of Medicine)
Microbial Modulation of Mucosal Restitution
2:00 PM - 2:30 PM Jason Spence, PhD (University of Michigan)
Organoids as Tools to Understand Human Development and Organ Homeostasis

2:30 PM - 3:01 PM

2:30 PM - 2:33 PM



2:34 PM - 2:37 PM



2:38 PM - 2:41 PM



2:42 PM - 2:45 PM



2:46 PM - 2:49 PM


2:50 PM - 2:53 PM

Poster Blitzes: (3-minute poster presentations)
 

Roberto Mota Alvidez - "Development of the First Animal Model of Dyslipidemia, Atherosclerosis, and Diabetes in Mutant apoE Deficient/ZDF Rats"
(Abstract # ACD1)

 

Matthias Kelm - "Targeting Epithelial Expressed Sialyl Lewis A Increases Intestinal Barrier Integrity, Improves Mucosal Wound Healing and Protects Against Colitis"
(Abstract # EMP1)

 

Shengmin Yan - "Autophagy Regulation of Ethanol-Induced Liver Injury Is Affected By Multiple Factors"
(Abstract # PLK3)

 

Bejan Saeedi - "Regulation of Oxidative Liver Injury by the Probiotic Lactobacillus Rhamnosus GG"
(Abstract # GMD1)

 

Xiaojiaoyang Li - "Cholangiocyte-derived Exosomal lncRNA H19 Activates Hepatic Stellate Cells Under Cholestatic Conditions"
(Abstract # PLK4)

 

Rachel Zemans - "Single Cell RNA-Seq Identifies TGF-beta as a Critical Regulator of Lung Regeneration”
(Abstract # CIRSP7)

3:02 PM - 3:15 PM Break
3:15 PM - 3:30 PM Abstract-Driven Short Talk

Anny-Claude Luissint, PhD (University of Michigan)
"CAR-Like Membrane Protein (CLMP) is a New Regulator of Intestinal Mucosal Homeostasis and Repair After Injury"

(Abstract # EMP7)

3:30 PM - 4:10 PM Outstanding Investigator Award Lecture
Scott Oakes, MD (University of California, San Francisco)
The Unfolded Protein Response: Cancer Friend or Foe?
4:10 PM - 5:30 PM Poster Session (with refreshments)
 

          Poster Topic Categories:

Atherosclerosis and Cardiovascular Disease           ACD1 through ACD4
Cell Injury, Repair, and Signaling Pathways               CIRSP1 through CIRSP8
Epithelial and Mucosal Pathobiology                         EMP1 through EMP14
Gut Microbiome and Disease                                      GMD1 through GMD8
Infectious Diseases                                                       ID1 through ID4
Inflammation & Immunity                                             INIM1 through INIM12
Pulmonary Pathobiology                                               PP1 through PP4

6:30 PM An Evening at "The Big House"
The Jack Roth Stadium Club at Michigan Stadium

1201 S. Main Street, Ann Arbor, MI 48104

Monday, October 22

Vascular Pathobiology: Discovery at the Blood-Tissue Interface
Co-Chairs:
Richard Mitchell, MD, PhD (Brigham & Women's Hospital)
Denuja Karunakaran, PhD (University of Ottawa Heart Institute)

7:00 AM - 12:00 PM Registration
8:25 AM - 8:30 PM Welcome & Introductions
Asma Nusrat, MD and Charles Parkos, MD, PhD (University of Michigan)
8:30 AM - 9:00 AM Guillermo Garcia-Cardeña, PhD (Brigham and Women’s Hospital/Harvard Medical School)
New Insights into Flow-Dependent Vascular Endothelial Cell Function and Dysfunction
9:00 AM - 9:30 AM William Muller, MD, PhD (Northwestern University School of Medicine)
Border Crossings: Leukocyte/Endothelial Cell Interactions During Inflammation
9:30 AM - 9:45 AM Denuja Karunakaran, PhD (University of Ottawa Heart Institute)
RIPK1: A Novel Therapeutic Target to Treat Cardiometabolic Diseases
9:45 AM - 10:00 AM Abstract-Driven Short Talk

Fatemeh Fattahi, MD, PhD (University of Michigan Medical School)
"Molecular Basis for the Cardiomyopathy of Sepsis and How It May Be Averted"
(Abstract # INIM8)

10:00 AM - 10:15 AM Break
10:15 AM - 10:30 AM Abstract-Driven Short Talk

Amritha Justin (University of Pittsburgh)
"The Angiogenic Capability of Mesenchymal Stem Cells Coupled with Tenascin-C Under Hypoxic Conditions"
(Abstract # SCRM5)

10:30 AM - 11:00 AM Patricia D’Amore, PhD (Schepens Eye Institute, Massachusetts General Hospital and Harvard Medical School)
A Novel Role for the Endothelial Glycocalyx in the Regulation of Vascular Inflammation and Angiogenesis
11:00 AM - 11:40 AM Cotran Early Career Investigator Award Lecture
 John Hanna, MD, PhD (Brigham and Women's Hospital)
Protein Degradation and the Pathologic Basis of Disease
11:45 AM - 1:00 PM Awards Presentations Ceremony
1:15 PM Conclusion